Timothy Newhouse

Research

Despite the power of modern organic chemistry, efficient synthesis of complex molecular scaffolds remains an unmet challenge. Their intricate ring systems and stereochemical arrays require too many synthetic operations to rapidly produce libraries of analogs. New technological approaches are needed to forge their varied bonds to provide scalable access to libraries of these molecular architectures. Through detailed mechanistic study, such technologies can be developed.

The development of general construction reactions has broad utility in a range of fields that rely on the synthesis of small molecules and functional materials. One particular area that we focus on is the total chemical synthesis of frameworks that are known to elicit powerful neurological effects. These substances serve as chemical probes to study fundamental aspects of neurological function and to address neurological dysfunction.

Education

B.A. Colby College, 2005
Ph.D. The Scripps Research Institute, 2010
Postdoctoral Fellow, Harvard University, 2010-2013

Honors

• Anderson Award, 2014
• Thieme Chemistry Journal Award, 2015
• Rosenkranz Award, 2015
• NSF CAREER, 2017
• Sloan Research Fellowship, 2017
• Academic Young Investigator, American Chemical Society, 2017
• Dylan Hixon ‘88 Prize for Teaching Excellence, 2018
• Amgen Young Investigator Award, 2018
• Camille Dreyfus Teacher-Scholar Award, 2019
• PRF New Directions, American Chemical Society, 2019
• Arthur C. Cope Scholar Early Career, American Chemical Society, 2019
• Genentech Research Innovation Award, 2020
• Boehringer Ingelheim Scientific Advancement Grant, 2021
• Boehringer Ingelheim Collaborative Research Award, 2022
• Yale University Art Gallery – Poorvu Award, 2024

Recent Publications

W. Lu, Haote Li, J. P. Menzel, A. E. Cuomo, A. M. Nikolic, H. Ray Kelly, Y. Shee, S. Sreekumar, F. Buono, J. J. Song, R. H. Crabtree,* V. S. Batista,* and T. R. Newhouse.* Methodical Ligand Selection by Generative Modeling with Latent-Space Sampling: Application to the Mizoroki-Heck Reaction [ChemRxiv]
 

Y. Shee, H. Li, P. Zhang, A. Nikolic, S. Sreekumar, F. Buono, J. Song, T. R. Newhouse,* V. Batista.* “Site-Specific Template Generative Approach for Retrosynthetic Planning.” Nature Commun. 2024, 7818
 

A. K. Bodnar, T. R. Newhouse.* “Accessing Z-Enynes via Cobalt-Catalyzed Propargylic Dehydrogenation.” Angew. Chem. Int. Ed. 2024, 63, e202402638.
 

A. Cuomo, S. Ibarraran, S. Sreekumar, H. Li, J. Eun, J. P. Menzel, P. Zhang, F. Buono, J. Song, R. H. Crabtree, V. Batista,* T. Newhouse.* “Feed Forward Neural Network for Predicting Enantioselectivity of the Asymmetric Negishi Reaction.” ACS Cent. Sci. 2023, 9, 1768.
 

D. E. Kim, Y. Zhu, I. Aguilar, S. Harada, M. Wang and T. R. Newhouse.* “Total Synthesis of (+)-Shearilicine.” J. Am. Chem. Soc. 2023, 145, 4394.
 

P. Zhang, J. Eun, M. Elkin, Y. Zhao, R. L. Cantrell, and T. R. Newhouse.* “A Neural Network Model Informs Total Synthesis of Clovane Sesquiterpenoids” Nature Synth. 2023, 2, 527.