portrait of a man

Frederick Ziegler

Professor Emeritus of Chemistry

Member of Yale faculty since 1965.
Not accepting lab members at this time.

Research Interest

Organic Chemistry

Contact Info

frederick.ziegler@yale.edu

SCL 132

Research 

Current research interests are focused on the development and use of radical reactions in organic synthesis.

Education

B.S. Fairleigh Dickinson University, 1960
M.S. Columbia University, 1961
Ph.D. Columbia University, 1964
NSF Postdoctoral Fellow, Massachusetts Institute of Technology, 1965

Honors

  • NIH Career Development Award, 1973-78
  • NIH Medicinal Chemistry A Study Section, 1979-83
  • Naito (Japan) Memorial Fellow, 1986
  • Greater Manchester (UK) Lecturer, 1994

Recent Publications

F.E. Ziegler & M.Y. Berlin. A Synthesis of (+)-9a-Desmethoxymitomycin A via Aziridinyl Radical Cyclization. Tetrahedron Lett. 1998, 39, 2455.

F.E. Ziegler & Y. Wang. Free Radical Studies and Solutions to the Synthesis of (+)-Cyclophellitol. J. Org. Chem. 1998, 63, 7920.

F.E. Ziegler, M.Y. Berlin, K. Lee, & A.R. Looker. Formation of 9,10-Unsaturation in the Mitomycins: Facile Fragmentation of ß-Alkyl-ß-aryl-α-oxo-γ-butyrolactones. Organic Lett. 2000, 2, 3619.

F.E. Ziegler, R.X. Kover, & N.N.K. Yee. Studies Directed Toward the Synthesis of FS-2: Observations on the Fragmentation of Cyclobutylcarbinyl Radicals.Tetrahedron Lett. 2000, 41, 5155.

F.E. Ziegler & M.A. Sarpong. Radical Cyclization Studies Directed Toward the Synthesis of BMS-200475 ‘Entecavir’: The Carbocyclic Core. Tetrahedron(Symposium-in-Print) 2003, 59, 9013.