Timothy Newhouse

Timothy Newhouse's picture
Associate Professor of Chemistry
Address: 
225 Prospect St, New Haven, CT 06511-8499
203 432 8316

Member of Yale faculty, starting 2013

Research

Despite the power of modern organic chemistry, efficient synthesis of complex molecular scaffolds remains an unmet challenge. Their intricate ring systems and stereochemical arrays require too many synthetic operations to rapidly produce libraries of analogs. New technological approaches are needed to forge their varied bonds to provide scalable access to libraries of these molecular architectures. Through detailed mechanistic study, such technologies can be developed.

The development of general construction reactions has broad utility in a range of fields that rely on the synthesis of small molecules and functional materials. One particular area that we focus on is the total chemical synthesis of frameworks that are known to elicit powerful neurological effects. These substances serve as chemical probes to study fundamental aspects of neurological function and to address neurological dysfunction.

Education

B.A. Colby College, 2005
Ph.D. The Scripps Research Institute, 2010
Postdoctoral Fellow, Harvard University, 2010-2013

Honors

2019          Arthur C. Cope Scholar Early Career, American Chemical Society
2019          PRF New Directions, American Chemical Society
2019          Camille Dreyfus Teacher-Scholar Award
2018          Amgen Young Investigator Award
2018          Dylan Hixon ‘88 Prize for Teaching Excellence
2017          Academic Young Investigator, American Chemical Society
2017          Sloan Research Fellowship
2017          NSF CAREER
2015          Rosenkranz Award
2015          Thieme Chemistry Journal Award
2014          Anderson Award

Recent Publications

A. W. Schuppe, Y. Zhao, Y. Liu, T. R. Newhouse. “Total Synthesis of (+)-Granatumine A and Related Bislactone Limonoid Alkaloids via a Pyran to Pyridine Interconversion.” J. Am. Chem. Soc. 2019, 141, 919.

A. Turlik, Y. Chen, A. C. Scruse, and T. R. Newhouse. “Convergent Total Synthesis of Principinol D, a Rearranged Kaurane Diterpenoid.” J. Am. Chem. Soc. 2019, 141, 8088.

D. Huang, S. M. Szewczyk, P. Zhang, T. R. Newhouse. “Allyl-Nickel Catalysis Enables Carbonyl Dehydrogenation and Oxidative Cycloalkenylation of Ketones” J. Am. Chem. Soc. 2019, 141, 5669.

D. E. Kim, J. E. Zweig, T. R. Newhouse. “Total Synthesis of Paspaline A and Emindole PB Enabled by Computational Augmentation of a Transform-Guided Retrosynthetic Strategy” J. Am. Chem. Soc. 2019, 141, 1479.

M. Elkin, A. C. Scruse, A. Turlik, T. R. Newhouse.* “Computational and Synthetic Investigation of Cationic Rearrangement in the Putative Biosynthesis of Justicane Triterpenoids” Angew. Chem. Int. Ed. 2019, 58, 1025.

Research Interests

Room Number: 
CRB 224