Sarah Slavoff

Sarah Slavoff's picture
Assistant Professor of Chemistry and of Molecular Biophysics and Biochemistry
300 Heffernan Dr. # B27, West Haven, CT 06516
+1 (203) 737-8670

Member of the Chemical Biology Institute 
Member of Yale faculty since 2014


The Slavoff lab is interested in developing new tools to elucidate novel functions of RNA in cells, including non-canonical translation and RNA degradation in cytoplasmic granules. We utilize a broad range of interdisciplinary methods, including mass-spectrometry-based proteomics, microscopy, structural biology, and small molecule-mediated control of biomolecular function.


B.S. University of Maryland, College Park, 2005
Ph.D. Massachusetts Institute of Technology, 2010
NIH Ruth L. Kirchstein Postdoctoral Fellow, Harvard University, 2010-14


2016 Searle Scholar
2017 Leukemia Research Foundation Hollis Brownstein Research Grant

Recent Publications

Y. Luo, Z. Na, S. A. Slavoff. “P-bodies: composition, properties and functions.” Biochemistry, 2018, early online.

R. Aebersold et al. “How many human proteoforms are there?” Nature Chemical Biology, 2018, 14(3): 206-214.

P. Yuan, N. G. D’Lima, S. A. Slavoff. “Comparative membrane proteomics reveals a nonannotated E. coli heat shock protein.” Biochemistry, 2018, 57, 56-69.

N. G. D’Lima, A. Khitun, A. D. Rosenbloom, P. Yuan, B. M. Gassaway, K. W. Barber, J. Rinehart, S. A. Slavoff. “Comparative proteomics enables identification of nonannotated cold shock proteins in E. coli.” Journal of Proteome Research, 2017, 13, 3722-3731.

N. G. D’Lima, J. Ma, L. Winkler, Q. Chu, K. H. Loh, E. O. Corpuz, B. A. Budnik, J. Lykke-Andersen, A. Saghatelian, S. A. Slavoff. “A human microprotein that interacts with the mRNA decapping complex.” Nature Chemical Biology, 2017, 13, 174-180.

S. A. Slavoff, A. J. Mitchell, A. G. Schwaid, M. N. Cabili, J. Ma, J. Z. Levin, A. D. Karger, B. A. Budnik, J. L. Rinn, A. Saghatelian. “Peptidomic discovery of short open reading frame-encoded peptides in human cells.” Nature Chemical Biology, 2013, 9, 59-64.

Research Interests

Room Number: 
CRB 116