Member of the Microbial Sciences Institute
Member of Yale faculty since 2017
Molecular interactions between microbial and host cells can profoundly impact human health and disease. My laboratory studies enzymes and other proteins that dynamically shape these interactions in the context of gastrointestinal infections. We use a technique called activity-based proteomics to identify proteins that are active in infected cells and animals using chemical probes designed to selectively label, enrich, and quantify reactive amino acids in complex proteomes. We are applying these probes to uncover secreted enzymes that mediate host-microbe interactions in the gut. We are also using probes that target redox-sensitive cysteines to understand how reactive oxygen species produced during bacterial infections influence intercellular signaling at the host-microbe interface through the oxidation of protein thiols. By chemically dissecting the functional proteome of bacterial infections, we aim to build a quantitative, molecular understanding of biochemical pathways that underlie the development of disease and generate new leads for therapeutic targets, activity-based diagnostics, and drug delivery systems.
B.S., Massachusetts Institute of Technology, 2005
Ph.D., University of California, Berkeley, 2010
Charles A. King Trust Postdoctoral Fellow, Harvard Medical School and Brigham and Women’s Hospital, 2011-2016
Thomas C. Alber Science and Engineering for Global Health Fellowship, 2010
NIH Ruth L. Kirschstein National Research Service Award (T32), 2013
Charles A. King Trust Postdoctoral Fellowship, 2014-2016
American Cancer Society Institutional Research Grant Pilot Award, 2018
Scialog Fellow: Microbiome, Neurobiology and Disease, 2020
Beckman Young Investigator Award, 2020
NIGMS Maximizing Investigators’ Research Award (MIRA) for Early Stage Investigators, 2020
Yale Cancer Center Pilot Award, 2020
Conquer Cancer Now Award, 2020
Kovalyova Y, Bak DW, Gordon EM, Fung C, Shuman JHB, Cover TL, Amieva MR, Weerapana E, and Hatzios SK. (2022) “An infection-induced oxidation site regulates legumain processing and tumor growth,” Nat Chem Biol 18: 698-705.
Gordon EM and Hatzios SK. (2020) “Chemical tools for decoding redox signaling at the host–microbe interface,” PLoS Pathog 16(12): e1009070.
Howell M, Dumitrescu DG, Blankenship LR, Herkert D, and Hatzios SK. (2019) “Functional characterization of a subtilisin-like serine protease from Vibrio cholerae,” J Biol Chem 294: 9888-9900.
Kovalyova Y and Hatzios SK. (2019) “Activity-based protein profiling at the host-pathogen interface,” Curr Top Microbiol Immunol 420: 73-91.