Member of Yale faculty since 2021
- Chemical Biology
- Biophysical Chemistry
- Physical Chemistry
- Analytical Chemistry
The overarching goal of my laboratory is to develop methods that allow for mass spectrometry (MS) analysis of mucin-domain glycoproteins, a class of densely O-glycosylated extracellular proteins. We will also study mucins in a biological context, since these proteins are integral in numerous diseases including: cancer, cystic fibrosis, and inflammatory bowel disease (IBD). My expertise in MS instrumentation and data analysis, combined with my experience in chemical biology and glycobiology, gives my laboratory a unique ability to tackle long-standing challenges associated with glycoproteomics. These studies will ultimately allow us to unravel the complex relationship between mucins and human disease.
B.S. University of Michigan, 2009
Ph.D. University of Virginia, 2014
Postdoctoral Scholar, Stanford University, 2016-2020
University of Michigan Honors, 2007-2009
University of Michigan Angell Scholar, 2009
Alpha Chi Sigma Presidential Award, 2010
University of Virginia Chemistry Department Fellowship, 2010-2013
Pratt Fellowship, 2013
Huskey Research Symposium Poster; First Place, 2013
Robert J. Huskey Travel Fellowship Recipient, 2014
Washington-Baltimore Mass Spectrometry Discussion Group Travel Award, 2014
Huskey Research Symposium Oral Presentation; First Place, 2014
University of Virginia 3 Minute Thesis; First Place, 2014
Achievement Rewards for College Scientists (ARCS), Danaher Scholar, 2013-2014
University of Virginia Post Doc Symposium Oral Presentation; Third Place, 2015
University of Virginia CGS/ProQuest Distinguished Dissertation Nominee, 2015
National Research Council (NRC) Research Associateship Award (Declined), 2016
Stanford University Mass Spectrometry Seed Grant, 2016
Helena Anna Henzl-Gabor Young Women in Science Travel Grant, 2017
NIH T32 Stanford School of Medicine Immunology Training Grant (Declined), 2017-2018
NIH F32 Ruth L. Kirschstein National Research Service Award (NRSA), 2017-2019
France-Stanford Center for Interdisciplinary Studies Visiting Junior Scholar Fellowship, 2018
SUMS Research Symposium Poster; First Place, 2018
Helena Anna Heenzl-Gabor Young Women in Science Travel Grant, 2018
Gordon Research Conference in Glycobiology; Poster Award, 2019
Society for Glycobiology Annual Conference Travel Award, 2019
Human Proteome Organization Early Career Researcher Manuscript Competition – Finalist, 2021
Royal Society for Chemistry - Chemistry Biology Interface Division Horizon Prize, 2021
American Society for Biochemistry and Molecular Biology (ASBMB) Early Career Faculty Award, 2021
Rising Stars in Proteomics and Metabolomics: 40 under 40, 2021
Stacy A. Malaker*ǂ, Nicholas M. Rileyǂ, D. Judy Shon, Kayvon Pedram, Venkatesh Krishnan, Oliver Dorigo, and Carolyn R. Bertozzi*. Revealing the human mucinome. Nature Communications. 2022, 13: 3542.
Ieva Bagdonaiteǂ, Stacy A. Malakerǂ, Daniel A. Polaskyǂ, Nicholas M. Rileyǂ, Katrine Schjoldager, Sergey Y. Vakhrushev, Adnan Halim, Kiyoko F. Aoki-Kinoshita, Alexey I Nesvizhskii, Carolyn R. Bertozzi, Hans Wandall, Benjamin L. Parker, Morten Thaysen-Andersen, and Nichollas E. Scott. Glycoproteomics. Nature Reviews Methods Primers. 2022, 2 (1): 1-29.
Deniz Ince, Taryn M. Lucas, and Stacy A. Malaker*. Current strategies for characterization of mucin-domain glycoproteins. Current Opinion in Chemical Biology. 2022, 69, 102174.
Valentina Rangel-Angarita and Stacy A. Malaker*. Mucinomics as the next frontier of mass spectrometry. ACS Chemical Biology. 2021, 16(10): 1866-1883.
Beatriz Calle‡, Ganka Bineva-Todd‡, Andrea Marchesi‡, Helen Flynn, Mattia Ghirardello, Omur Y. Tastan, Chloe Roustan, Junwon Choi, M. Carmen Galan, Benjamin Schumann*, and Stacy A. Malaker*. Benefits of chemical sugar modifications introduced by click chemistry for glycoproteomic analyses. Journal of the American Society for Mass Spectrometry. 2021, 32(9): 3266-2375.
Stacy A. Malakerǂ, Kayvon Pedramǂ, Michael J. Ferracane, Barbara A. Bensing, Venkatesh Krishnan, Christian Pett, Jin Yu, Elliot C. Woods, Jessica R. Kramer, Ulrika Westerlind, Oliver Dorigo, and Carolyn R. Bertozzi. The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins. Proceedings of the National Academy of Sciences USA. 2019, 116(15): 7278-7287.
* = corresponding author
† = co-first author