Scott Strobel

Professor of Chemistry
Member of Yale faculty since 1995

Research Interests


Research in the Strobel lab is divided between work on RNA biochemistry and the investigation of novel endophytic fungi associated with rainforest plants. The RNA analysis includes studies of the ribosome and riboswitches. The goal is to understand how RNA promotes chemical reactions and to define the basis of RNA-small molecule interactions. Our work in microbiobial diversity includes the investigation of fungal natural products and their bioactivity.


B.A. Brigham Young University, 1987
Ph.D. California Institute of Technology, 1992
Howard Hughes Medical Institute Predoctoral Fellow, Caltech, 1988-92
Postdoctoral Fellow, Biochemistry, University of Colorado, Boulder, 1992-95


HHMI Predoctoral Fellow, Caltech, 1988-92
Life Sciences Research Foundation Fellow, CU Boulder, 1992-95
Beckman Young Investigator Award, Yale University, 1997-99
Searle Scholar Award, Yale University, 1997-2000
Beginning Investigator Award, American Cancer Society, Yale University, 2002-06
Dylan Hixon Prize for Teaching Excellence in the Natural Sciences, Yale University, 2004
Howard Hughes Medical Institute Professor
Graduate Mentoring Award in the Sciences, Yale University, 2007
Schering Plough Research Institute Award from the ASBMB, 2008
Elected member of the Connecticut Academy of Science and Engineering, 2012

Recent Publications

D.A. Hiller, V. Singh, M. Zhong & S.A. Strobe., A two-step chemical mechanism for ribosome-catalyzed peptide bond formation. Nature 2011, 476, 236–239.

C.A. Bascom-Slack, A.E. Arnold & S.A. Strobel. Student-directed discovery of the plant microbiome and its natural products. Science 2012, 338, 485-86.

C.A. Shanahan, B.L. Gaffney, R.A. Jones & S.A. Strobel. Identification of c-di-GMP derivatives resistant to an EAL domain phosphodiesterase. Biochemistry2013, 52, 365-377.

M.A. Griffin, J.H. Davis & S.A. Strobel. Bacterial toxin RelE: A highly efficient nuclease with exquisite substrate specificity using atypical catalytic residues.Biochemistry 2013, 52, 8633-42.

K.M. Ruff & S.A. Strobel. Ligand binding by the tandem glycine riboswitch depends on aptamer dimerization but not double ligand occupancy. RNA 2014,20, 1775-88.