Frederick Ziegler

Member of Yale faculty since 1965

Research Interest


Current research interests are focused upon the development and use of radical reactions in organic synthesis.


B.S. Fairleigh Dickinson University, 1960
M.S. Columbia University, 1961
Ph.D. Columbia University, 1964
NSF Postdoctoral Fellow, Massachusetts Institute of Technology, 1965


NIH Career Development Award, 1973-78
NIH Medicinal Chemistry A Study Section, 1979-83
Naito (Japan) Memorial Fellow, 1986
Greater Manchester (UK) Lecturer, 1994

Recent Publications

F.E. Ziegler & M.Y. Berlin. A Synthesis of (+)-9a-Desmethoxymitomycin A via Aziridinyl Radical Cyclization. Tetrahedron Lett. 1998, 39, 2455.

F.E. Ziegler & Y. Wang. Free Radical Studies and Solutions to the Synthesis of (+)-Cyclophellitol. J. Org. Chem. 1998, 63, 7920.

F.E. Ziegler, M.Y. Berlin, K. Lee, & A.R. Looker. Formation of 9,10-Unsaturation in the Mitomycins: Facile Fragmentation of ß-Alkyl-ß-aryl-α-oxo-γ-butyrolactones. Organic Lett. 2000, 2, 3619.

F.E. Ziegler, R.X. Kover, & N.N.K. Yee. Studies Directed Toward the Synthesis of FS-2: Observations on the Fragmentation of Cyclobutylcarbinyl Radicals.Tetrahedron Lett. 2000, 41, 5155.

F.E. Ziegler & M.A. Sarpong. Radical Cyclization Studies Directed Toward the Synthesis of BMS-200475 ‘Entecavir’: The Carbocyclic Core. Tetrahedron(Symposium-in-Print) 2003, 59, 9013.