David Spiegel

Member of Yale faculty since 2007

Research Interests


The Spiegel lab develops novel chemical methods to enable the synthesis of a variety of complex molecular targets, including natural products. These synthetic materials will be used to study the molecular mechanisms that underlie human disease processes (e.g., cancer, Alzheimer’s disease, and diabetes) as well as to develop novel therapeutic approaches to these conditions. Overall, students in the Spiegel lab receive in-depth training in organic synthesis as well as to techniques in molecular and cellular biology.


NIH Postdoctoral Fellow, Harvard University (Stuart L. Schreiber), 2005-2007
M.D. Yale University, 2004
Ph.D. Yale University (John L. Wood), 2004 
A.B. Harvard University, 1995


American Diabetes Association Pathway to Stop Diabetes Visionary Award, 2017
Arthur Cope Scholar Award, American Chemical Society, 2015
American Chemical Society Committee on Science Young Investigator Awardee, 2013
Department of Defense CDMRP Breast Cancer Era of Hope Scholar Award, 2013
ACS Medicinal Chemistry Young Investigator Award Symposium Speaker, 2012
Bristol-Myers Squibb Innovation Award, 2012
Novartis Early Career Award in Organic Chemistry (one of two recipients worldwide), 2011
Kavli Institute Frontiers of Science Fellowship, 2011
Alfred P. Sloan Foundation Fellowship, 2011
Nature Chemical Biology Grand Challenges Essay Contest, 2010
Bill and Melinda Gates Foundation Grand Challenges Explorations Award, 2009-present
Ellison Medical Foundation New Scholar Award, 2008-present
NIH Director’s New Innovator Award, 2007-present
Dreyfus New Faculty Award 2007-present
NIH Ruth L. Kirchstein National Research Service Award Fellowship, 2005-07
NIH Cancer Education Program Fellowship, 2001-02
Rotary Foundation Walter D. Head Memorial Fellowship for Study Abroad, 1995-96
Barry M. Goldwater Fellowship for Excellence in Science, 1994-95
Rockefeller University Summer Undergraduate Research Fellowship, 1994 
John Harvard Fellowship (awarded by semester), 1992-95

Recent Publications

Exploring Binding and Effector Functions of Natural Human Antibodies Using Synthetic Immunomodulators. Jakobsche CE, Parker CG, Tao RN, Kolesnikova MD, Douglass Jr. EF, Spiegel DA. ACS Chem. Biol., 2013, 8(11), 2404-2411.

Illuminating HIV gp120-Ligand Recognition through Computationally-Driven Optimization of Antibody-Recruiting Molecules. Parker CG, Dahlgren MK. Tao RN, Li DT, Douglass EF, Shoda T, Jawanda N, Spasov KA, Lee S, Zhou N, Domaoal RA, Sutton RE, Anderson KS, Jorgensen WL, Krystal M, Spiegel DA. Chem. Sci., 2014, 5(6), 2311-2317.

Click-coated, Heparinized, Decellularized Vascular Grafts. Dimitrievska S, Cai C, Weyers A, Balestrini JL, Lin T, Sundaram S, Hatachi G, Spiegel DA, Kyriakides TR, Miao J, Li G, Niklason LE, Linhardt RJ. Acta Biomater., 2015, 13, 177-187.

Chemical Probes Reveal and Extraseptal Mode of Cross-linking in Staphylococcus Aureus. Gautam S, Kim T, Spiegel DA. J. Am. Chem. Soc., 2015, 137(23), 7441-7447.

An Activity-based Probe for Studying Crosslinking in Live Bacteria. Gautam S, Kim T, Shoda T, Deep D, Luthra R. Lester ET, Ferreira MT, Pinho MG, Spiegel DA. Angew. Chem. Int. Ed., 2015, 54(36), 10492-10496.

Concise total synthesis of glucosepane. Draghici C, Wang T, Spiegel DA. Science, 2015, 350(6258), 294-298. *Featured in Science

Re-engineering the Immune Response to Metastatic Cancer: Antibody-Recruiting Small Molecules Targeting the Urokinase Receptor. Rullo AF, Fitzgerald KJ, Muthusamy V, Liu M, Yuan C, Huang M, Kim M, Cho AE, Spiegel DA. Angew. Chem. Int. Ed., 2016, 7;55 (11), 3642-3646.

Neutralization of Pathogenic Fungi with Small-Molecule Immunotherapeutics. Angew. Chem. Int. Ed. 2017, 56 (42), 13036-13040.