Join Yale Chemistry for a Sigma-Aldrich Organic Chemistry Lecture with Mary P. Watson, Professor, Department of Chemistry & Biochemistry, University of Delaware.
Title: Deaminative Cross-Couplings
Alkyl amines are widely available in both simple building blocks and late-stage intermediates. In addition, the amino group (NH2) can be carried through multi-step syntheses in protected form, and enables straightforward purification. These features are well appreciated in the use of alkyl amines for the preparation of nitrogen-containing products. We are expanding the toolkit of reactions of alkyl amines by developing cross-coupling reactions via cleavage of their carbon–nitrogen bonds. These reactions rely on the use of nickel catalysts to efficiently convert alkyl amine derivatives into a variety of products, and provide new opportunities for the use of amines in synthesis. Our more recent work with new coupling partners and new classes of alkyl pyridinium salts will also be presented.
Date: September 27, 2023
Time: 4 pm
Location: SCL 110
Faculty Host: Scott Miller
This seminar is generously sponsored by Sigma-Aldrich