Please join Yale Chemistry for a GlaxoSmithKline organic chemistry seminar with Andy McNally, Associate Professor and Albert I. Meyers Chair in Chemistry, Colorado State University.
Abstract: Pyridines and diazines are ubiquitous in pharmaceuticals and agrochemicals, yet there are limits in synthetic methods that can directly functionalize the C–H bonds in these structures. We will show two distinct approaches, using phosphorus and ring-opened intermediates, that enable selective functionalization of these heterocycles into a range of valuable derivatives. A range of C–C and C–Heteroatom bond formations are viable, and the chemistry functions on structures typically encountered in drug discovery programs. Our lab has also performed mechanistic and computational studies of the regioselectivity of these reactions and the phosphorus ligand-coupling processes involved. For more information on Prof. McNally’s research: https://www.mcnallygroup.org/andy
Faculty Host: Prof. John Ellman
This seminar can be viewed online here: Panopto