Join Yale Chemistry for a Silliman Organic Chemistry Seminar with Mingji Dai, ASA Griggs Candler Professor of Chemistry, Emory University
Abstract: This talk will focus on our recent efforts in function and efficiency-driven total synthesis of medicinally important natural products. The target molecules include macrolides, alkaloids, and polycyclic diterpenoids. Novel and enabling synthetic strategies and methodologies toward these target molecules will be highlighted. Biological evaluation and target identification of the selected natural products and their analogs will be discussed as well. These biological endeavors have led us to the exciting territories of targeting the previously undruggable disease proteins via small-molecule inhibition and targeted protein degradation Overall, this talk will emphasize how we use natural product total synthesis to achieve chemistry innovation and biological discovery.
More information on the Dai Lab can be found here: The Dai Research Group (emorychem.science)
Hosted by Professor Mark Johnson
This seminar is generously sponsored by the Mrs. Hepsa Ely Silliman Memorial Fund
This seminar can be viewed online here: Panopto