Member of the Microbial Sciences Institute
Member of Yale faculty since 2017
Molecular interactions between microbial and host cells can profoundly impact human health and disease. My laboratory studies enzymes and other proteins that dynamically shape these interactions in the context of gastrointestinal infections. We use a technique called activity-based proteomics to identify proteins that are active in infected cells and animals using chemical probes designed to selectively label, enrich, and quantify reactive amino acids in complex proteomes. We are applying these probes to uncover secreted enzymes that mediate host-microbe interactions in the gut. We are also using probes that target redox-sensitive cysteines to understand how reactive oxygen species produced during bacterial infections influence intercellular signaling at the host-microbe interface through the oxidation of protein thiols. By chemically dissecting the functional proteome of bacterial infections, we aim to build a quantitative, molecular understanding of biochemical pathways that underlie the development of disease and generate new leads for therapeutic targets, activity-based diagnostics, and drug delivery systems.
B.S., Massachusetts Institute of Technology, 2005
Ph.D., University of California, Berkeley, 2010
Charles A. King Trust Postdoctoral Fellow, Harvard Medical School and Brigham and Women’s Hospital, 2011-2016
Beckman Young Investigator Award, 2020
Scialog Fellow: Microbiome, Neurobiology, and Disease, 2020
Finalist, Damon Runyon-Rachleff Innovation Award, 2018
American Cancer Society Institutional Research Grant Pilot Award, 2018
Charles A. King Trust Postdoctoral Fellowship, 2014-2016
Thomas C. Alber Science and Engineering for Global Health Fellowship, 2010
Outstanding Graduate Student Instructor Award, UC Berkeley, 2008
Howell M, Dumitrescu DG, Blankenship LR, Herkert D, and Hatzios SK. (2019) “Functional characterization of a subtilisin-like serine protease from Vibrio cholerae,” J Biol Chem 294: 9888-9900.
Kovalyova Y and Hatzios SK. (2019) “Activity-based protein profiling at the host-pathogen interface,” Curr Top Microbiol Immunol 420: 73-91.
Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gascon S, Hatzios SK, Kagan VE, Noel K, Jiang X, Linkermann A, Murphy ME, Overholtzer M, Oyagi A, Pagnussat GC, Park J, Ran Q, Rosenfeld CS, Salnikow K, Tang D, Torti FM, Torti SV, Toyokuni S, Woerpel KA, and Zhang DD. (2017) “Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease,” Cell 171: 273-285.
Hatzios SK, Abel S, Martell J, Hubbard T, Sasabe J, Munera D, Clark L, Bachovchin DA, Qadri F, Ryan ET, David BM, Weerapana E, and Waldor MK. (2016) “Chemoproteomic profiling of host and pathogen enzymes active in cholera,” Nat Chem Biol 12: 268-274.
- Chemical Biology