Professor of Chemistry
Member of Yale faculty since 1971
Our lab is concerned with the function and structure of ribonuclease P in both bacteria and human cells. We investigate the properties of these enzymes and what they are doing in vivo. We are also exploring the use of RNase P and so-called external guide sequences to activate various genes in bacteria and mammalian cells.
B.S. Massachusetts Institute of Technology, 1960
Ph.D. University of Colorado, 1967
Postdoctoral Fellow, Harvard University, 1967-69
Visiting Research Fellow, MRC Laboratory, Cambridge, England, 1969-71
Nobel Prize in Chemistry, 1989
American Academy of Arts and Sciences, National Academy of Sciences, 1990
Honorary Degrees: Université de Montréal 1990, York University (Toronto) 1990, Connecticut College 1990, McGill University 1991, University of Colorado 1991, University of British Columbia 1991, Dartmouth College 1996
D.A. Pomeranz Krummel & S. Altman. Verification of phylogenetic predictions in vivo and the importance of the tetraloop motif in a catalytic RNA. Proc. Nat. Acad. Sci. USA 1999, 96, 11200-11205.
V. Gopalan, A. Vioque, & S. Altman. Varieties of RNase P: A nomenclature problem? RNA 2000, 6, 1689-1694.
T. Jiang & S. Altman. Protein-protein interactions with subunits of human nuclear RNase P. Proc. Nat. Acad. Sci. USA 2001, 98, 920-925.
Y. Li & S. Altman. A subunit of human nuclear RNase P has ATPase activity.Proc. Nat. Acad. Sci. USA 2001, 98, 441-444.
R. Paul, D. Lazarev, & S. Altman. Characterization of RNase P from Thermotoga maritima. Nucl. Acids Res. 2001, 29, 880-885.