Ziad Ganim

Member of Yale faculty since 2014

Research Interests


Our research group is interested in mechanistic studies of chemical reactions at the single molecule level. Single molecule force manipulation and optical detection have revolutionized biophysics by characterizing states and kinetics traditionally obscured in ensemble averages; the development of single molecule vibrational spectroscopies will provide the structural resolution necessary to extend these tools to study chemical processes such as bond formation and dissociation, charge transfer, and ligand exchange. We will apply an array of single molecule techniques to study how metalloproteins facilitate redox chemistry in their active sites and to study mechanistic heterogeneity during carbon-carbon bond formation in organometallic catalysts. New theoretical and computational methods will be developed to understand these new spectroscopies and model reaction pathways.


B.S. University of California, Berkeley, 2003
Ph.D. Massachusetts Institute of Technology, 2010
Postdoctoral Fellow, Technical University of Munich, 2010-2014


Alexander von Humboldt Postdoctoral Fellowship, 2010-2012
Poitras Predoctoral Fellowship, 2008-2009
MIT Chemistry Outstanding Teaching Award, 2004
University of California Departmental Citation in Chemistry, 2003

Recent Publications

Parobek, AP, Black, JW, Kamenetska, M, Ganim, Z. Force-Detected Nanoscale Absorption Spectroscopy in Water at Room Temperature using an Optical Trap (Feature Article). J. Chem. Phys., In press.

Black, JW, Kamenetska, M, Ganim, Z. An Optical Tweezers Platform for Single Molecule Force Spectroscopy in Organic Solvents. Nano Lett. 2017, 17(11): 6598-6605.

Ganim, Z, Rief, M. Mechanically Switching Single Molecule Fluorescence of GFP by Unfolding and Refolding. Proc. Natl. Acad. Sci. USA 2017, 114(42): 11052-11056.

Huang, J, Parobek, A, Ganim, Z. Octave-spanning mid-infrared pulses by plasma generation in air pumped with an Yb:KGW source. Optics Letters 2016, 41(21): 4855-4858.

Z. Ganim. Single-Molecule Vibrational Spectroscopy Adds Structural Resolution to the Optical Trap (New and Notable Commentary). Biophys. J. 2013, 104, 4-5.