Join Yale Chemistry for an Organic Chemistry Seminar with Sophie Rousseaux, Associate Professor, University of Toronto.
Title: New Strategies for the Synthesis of Small Rings and Nitrile Derivatives
Research in the Rousseaux group focuses on the development of new synthetic methods to selectively break and/or form new bonds in organic molecules, namely through the use of Ni catalysis. Our approach to method development relies on mechanistic studies to design improved catalysts and reaction conditions, ultimately leading to broader reaction scopes and the discovery of new reactivity. In this presentation, I will describe our efforts to develop new synthetic methods in two areas. In the first part of this talk, I will discuss our recent work on the synthesis and functionalization of cyclopropanols and cyclobutanols. Reactions involving electrophilic metal homoenolates1 will be presented as well as Ni-catalyzed cross-couplings of cyclopropanols. In part two, I will describe our current efforts in developing new synthetic methods for the preparation of nitrile-containing building blocks that use inexpensive and less toxic nitriletransfer reagents. Our work on the development of Ni-catalyzed reductive transnitrilation reactions will also be presented.
Date: February 8, 2023
Time: 4:00pm
Location: SCL160
This seminar is generously sponsored by the Mrs. Hepsa Ely Silliman Memorial Fund