Sarah Slavoff

Sarah Slavoff's picture
Assistant Professor of Chemistry and of Molecular Biophysics and Biochemistry
300 Heffernan Dr. # B27, West Haven, CT 06516
203 737 8670

Member of the Chemical Biology Institute 
Member of Yale faculty since 2014

Research The Slavoff lab is interested in developing new tools to elucidate novel functions of RNA in cells, including non-canonical translation, RNA degradation in cytoplasmic granules, and RNA trafficking. We will utilize a broad range of interdisciplinary methods, including mass spectrometry-based proteomics, microscopy, chemical synthesis, and light- and small molecule-mediated control of biomolecular function.


B.S. University of Maryland, College Park, 2005
Ph.D. Massachusetts Institute of Technology, 2010
NIH Ruth L. Kirchstein Postdoctoral Fellow, Harvard University, 2010-14


2016 Searle Scholar

Recent Publications

N. D’Lima, J. Ma, L. Winkler, K. H. Loh, Q. Chu, L. Corpuz, J. Lykke-Andersen, A. Saghatelian, S. A. Slavoff. A human short open reading frame-encoded polypeptide that interacts with the mRNA decapping complex. Nature Chemical Biology, 2016, In press.

S. A. Slavoff, J. Heo, B. A. Budnik, L. Hanakahi, A. Saghatelian. A human short open reading frame (sORF)-encoded polypeptide that stimulated DNA end joining. Journal of Biological Chemistry, 2014, 289, 10950-10957.

J. Ma, C. C. Ward, I. Jungreis, S. A. Slavoff, A. G. Schwaid, J. Neveu, B. A. Budnik, M. Kellis, A. Saghatelian. The discovery of human sORF-encoded polypeptides (SEPs) in cell lines and tissue. Journal of Proteome Research, 2014, 13, 1757-1765.

A. G. Schwaid, D. A. Shannon, J. Ma, S. A. Slavoff, J. Z. Levin, E. Weerapana, A. Saghatelian. Chemoproteomic discovery of cysteine-containing human sORFs. Journal of the American Chemical Society, 2013, 135, 16750-16753.

S. A. Slavoff, A. J. Mitchell, A. G. Schwaid, M. N. Cabili, J. Ma, J. Z. Levin, A. D. Karger, B. A. Budnik, J. L. Rinn, A. Saghatelian. Peptidomic discovery of short open reading frame-encoded peptides in human cells. Nature Chemical Biology, 2013, 9, 59-64.

Research Interests

Room Number: 
SCL 208