Member of Yale faculty since 2010
Research The Baxter lab is interested in the innate immune response of arthropods, especially the complement-like system in Anopheles gambiae, host-pathogen interactions, and the development of new chemical entities for the control of vector-borne disease. Our primary research tools are biophysical methods, including macromolecular crystallography and small-angle x-ray scattering, biochemistry and chemical biology. Our approach is multi-disciplinary and interfaces with both cross-campus and international collaborators studying vector biology and infectious disease.
B.Sc. (Hons.) Australian National University, 1998
Ph.D. University of Chicago, 2004
Boomerang Award, Australian National University, 2009
NIAID Research Scholar (K22) Award, 2010
For a list of recent publications, click here.
R.H.G. Baxter, S. Steinert, Y. Chelliah, G. Volohonsky, E.A. Levashina, & J. Deisenhofer. A heterodimeric complex of the LRR proteins LRIM1 and APL1C regulates complement-like immunity in Anopheles gambiae. Proc. Nat. Acad. Sci. USA 2010, 107, 16817-22. PMID: 20826443
M. Fraiture, R.H.G. Baxter, S. Steinert, Y. Chelliah, C. Frolet, W. Quispe-Tintaya, J.A. Hoffmann, S.A. Blandin, & E.A. Levashina. Two mosquito LRR proteins function as complement control factors in the TEP1-mediated killing of Plasmodium. Cell Host Microbe 2009, 5, 273-84. PMID: 19286136
R.H.G. Baxter, C.-I Chang, Y. Chelliah, S. Blandin, E.A. Levashina, & J. Deisenhofer. Structural basis for conserved complement factor-like function in the antimalarial protein TEP1. Proc. Nat. Acad. Sci. USA 2007, 104, 11615-20. PMID: 17606907
R.H. Baxter, N. Ponomarenko, V. Srajer, R. Pahl, K. Moffat & J.R. Norris. Time-resolved crystallographic studies of linght-induced structural changes in the photosynthetic reaction center. Proc. Nat. Acad. Sci. USA 2004, 101, 5982-7. PMID: 15073325