Nilay Hazari
Member of Yale faculty since 2009
Research Interests
Research
Research in the Hazari group involves synthetic inorganic and organometallic chemistry, with an emphasis on reaction mechanisms and catalysis. The long-term goal of most projects is to develop homogeneous transition metal catalysts for chemical transformations, which could result in the development of more energy-efficient and affordable industrial processes. Furthermore, we believe that it is important to understand reaction mechanisms, as this can play a crucial role in improving catalysts. A variety of techniques, including multinuclear NMR spectroscopy, IR and UV-Visible spectroscopy, mass spectrometry, X-ray crystallography, isotopic labeling studies, and computational chemistry, are used to characterize compounds, investigate reaction mechanisms, and perform kinetics studies. In addition, the Hazari group collaborates with various researchers both at Yale and other institutions to use organic and organometallic molecules to vary the properties of 2D materials.
More specifically, projects in the group relate to: 1) the development of catalysts for the hydrogenation of carbon dioxide into formic acid and methanol and the reverse dehydrogenation of formic acid and methanol into carbon dioxide and hydrogen; 2) fundamental understanding of the reactions between carbon dioxide and transition metal complexes; 3) the design of molecular catalysts attached to semiconductors for the photoreduction of carbon dioxide into liquid fuels; 4) understanding the role of Ni(I) complexes in organic transformations such as cross-coupling; and 5) the development of new catalysts and reagents for transition metal-mediated organic reactions, such as cross-electrophile coupling that will make reactions more sustainable. In most of the Hazari groups’ research, computational chemistry is used to support experimental observations.
Education
Postdoctoral Fellow, California Institute of Technology, 2006-2009
D.Phil. University of Oxford, 2006
M.S. University of Sydney, 2003
B.S. University of Sydney, 2002
Honors
Rhodes Scholarship for New South Wales, 2003
National Science Foundation Career Award, 2012
Organometallics Fellow (from the American Chemical Society Journal Organometallics), 2012
Alfred P. Sloan Research Fellow, 2013
Camille and Henry Dreyfus Teacher-Scholar Award, 2014
Selected as a ‘Rising Star’ by the 41st International Conference on Coordination Chemistry, 2014
Arthur Greer Memorial Prize for Outstanding Scholarship by Junior Faculty Members in the Social Sciences and Sciences at Yale University, 2015
American Chemical Society Harry Gray Award for Creative Work in Inorganic Chemistry by a Young Investigator, 2017
Elected as Member of the Connecticut Academy of Science and Engineering, 2020
Recent Publications
Charboneau, D. J.; Huang, H.; Barth, E. L.; Germe, C. C.; Hazari, N.; Mercado, B. Q.; Uehling, M. R.; Zultanski, S. L. ‘Tunable and Practical Homogeneous Organic Reductants for Cross-Electrophile Coupling.’ J. Am. Chem. Soc. 2021, 143, 21024-21036.
Curley, J. B.; Smith, N. E.; Bernskoetter, W. H.; Ertem, M. Z.; Hazari, N.; Mercado, B. Q.; Townsend, T. M.; Wang, X. ‘Understanding the Properties and Decomposition of Highly Active Iron Pincer Complexes for Hydrogenation and Dehydrogenation Reactions.’ ACS Catal. 2021, 11, 10631-10646.
Somerville, R. J.; Odena, C.; Obst, M. F.; Hazari, N.; Hopmann, K. H.; Martin, R. ‘Ni(I)-Alkyl Complexes Bearing Phenanthroline Ligands: Experimental Evidence for CO2 Insertion at Ni(I) Centers.’ J. Am. Chem. Soc. 2020, 142, 10936-10941.
Smith, N. E.; Bernskoetter, W. H.; Hazari, N. ‘The Role of Proton Shuttles in the Reversible Activation of Hydrogen via Metal-Ligand Cooperation.’ J. Am. Chem. Soc. 2019, 141, 17350-17360.
Heimann, J. E.; Bernskoetter, W. H.; Hazari, N. ‘Understanding the Individual and Combined Effects of Solvent and Lewis Acid on CO2 Insertion into a Metal Hydride.’ J. Am. Chem. Soc. 2019, 141, 10520-10529.
Mohadjer Beromi, M; Brudvig, G. W.; Hazari, N.; Lant, H. M. C.; Mercado, B. Q. ‘Synthesis and Reactivity of Paramagnetic Ni Polypyridyl Complexes Relevant to Csp2-Csp3 Coupling Reactions.’ Angew. Chem., Int. Ed. 2019, 58, 6094-6098.