James Mayer

James Mayer's picture
Charlotte Fitch Roberts Professor of Chemistry
Address: 
225 Prospect St, New Haven, CT 06511-8499
203 436 9456

Member of Yale faculty since 2014

Research Research in the Mayer group spans the fields of inorganic, materials, bioinorganic, organometallic, and physical organic chemistry. Our primary focus is on redox reactions that involve bond formation and bond cleavage, in particular the coupled transfers of protons and electrons. Proton/electron transfers are central to a variety of important processes, from fuel cells and solar fuels to bioenergetics, from organic free radical reactions and reactive oxygen species to enzymatic oxidations, and from the properties of nanoscale metal oxides to interfacial charge transfer.

One aspect of our work is developing fundamental descriptions of the different classes of proton-coupled electron transfer (PCET) reactions. We have shown, for instance, that hydrogen atom transfers are typically well described by a model based on Marcus Theory. Studies of photo-induced PCET in phenol derivatives are probing reactions near the barrierless limit. Transition metal complexes are being synthesized with separated redox and acid/base sites, to probe the effect of separating the H+ and e–,as models for biological PCET processes. PCET principles are being applied to the development and study of electrocatalysts for small molecule transformations, such as O2 + 4H+ + 4e → 2H2O, which is key to fuel cell and solar fuel technologies. The Mayer group has recently shown that PCET is also a key concept in materials chemistry and interfacial charge transfer reactions. For instance metal oxide nanocrystals can transfer H+ and e to organic reagents. The Figure below illustrates the similarity of this process with molecular separated PCET reactions.

The Mayer group thus works on a wide variety of systems, studying them by synthesizing new compounds, using spectroscopies of various kinds (e.g., optical, EPR, NMR), materials characterization (XRD, microscopy, NMR etc.), electrochemistry and electrocatalysis, kinetic studies including stopped-flow and laser-flash transient absorption techniques, and mechanistic studies. Cross fertilization among the different projects is stimulating for student growth and helps to develop new fundamental insights into chemical redox reactivity.

Education

A.B. Harvard University, 1978
Ph.D. California Institute of Technology, 1982

Honors

Presidential Young Investigator, National Science Foundation, 1988
Sloan Research Fellowship, Alfred P. Sloan Foundation, 1989
Polyhedron Best Paper Award, 1989
Innovation Recognition Program Awardee, Union Carbide, 1990-1991
E. Bright Wilson Prize Lecturer, Harvard University, 1992
Fellow, American Association for the Advancement of Science, 1998
Named Alvin L. and Verla R. Kwiram Professor of Chemistry at the University of Washington, 1999-2014
Chair, American Chemical Society Division of Inorganic Chemistry, 2000
Chair, Gordon Conference on Inorganic Reaction Mechanisms, 2003
E.L. King Lecturer at the University of Colorado, Boulder, 2001
Distinguished Summer Lecturer in Inorganic Chemistry, Northwestern University, 2001 
Reilly Lecturer at University of Notre Dame, 2003
Inaugural Paul Hopkins Faculty Award, University of Washington, 2004
Gerhard Closs Lecturer, University of Chicago, 2007
Nakamoto Distinguished Lecture in Chemistry, Marquette University, 2010
Debye Lecturer, Cornell University, 2010
Fellow of the American Chemical Society, 2011
Distinguished Summer Lecturer in Inorganic Chemistry, Northwestern University, 2012
Dow Lecturer in Inorganic Chemistry, University of California at Berkeley, 2012
Slayton Evans Lectureship, University of North Carolina, Chapel Hill, 2013
Chair, Gordon Research Conference on Metals in Biology, 2015
Kolthoff Lecturer, University of Minnesota, Twin Cities, 2015
Marry Kapp Lecture, Virginia Commonwealth University, 2015
Aldrich Lecturer, University of Wisconsin, 2015
Illinois Distinguished Lecture in Inorganic Chemistry, University of Illinois, April 2016
Barré Lectures, University of Montreal, 2016
Moses Gomberg Lecture, University of Michigan, 2017

Recent Publications

M. L. Pegis, B. A. McKeown, N. Kumar, K. Lang, D. J. Wasylenko, X. P. Zhang, S. Raugei, J. M. Mayer. Homogenous Electrocatalytic Oxygen Reduction Rates Correlate with Reaction Overpotential in Acidic Organic Solutions. ACS Cent. Sci. 2016, 2, 850-856. DOI: 10.1021/acscentsci.6b00261

C. N. Valdez, A. M. Schimpf, D. R. Gamelin, J. M. Mayer. Proton-Controlled Reduction of ZnO Nanocrystals: Effects of Molecular Reductants, Cations, and Thermodynamic Limitations. J. Am. Chem. Soc. 2016, 138, 1377-1385. DOI: 10.1021/jacs.5b12182

J. J. Warren, A. R. Menzeleev, J. S. Kretchmer, T. F. Miller III, H. B. Gray, & J. M. Mayer. Long-Range Proton-Coupled Electron-Transfer Reactions of Bis(imidazole) Iron Tetraphenylporphyrins Linked to Benzoates. J. Phys. Chem. Lett. 2013, 4, 519–523. DOI: 10.1021/jz400029w

J. N. Schrauben, R. Hayoun, C. N. Valdez, M. Braten, L. Fridley, J. M. Mayer. Titanium and Zinc Oxide Nanoparticles are Proton-Coupled Electron Transfer Agents. Science 2012, 336, 1298-1301. DOI: 10.1126/science.1220234

J. N. Schrauben, M. Cattaneo, T. C. Day, A. L. Tenderholt, & J. M. Mayer. Multiple-Site Concerted Proton-Electron Transfer Reactions of Hydrogen-Bonded Phenols are Non-adiabatic and Well Described by Semi-Classical Marcus Theory. J. Am. Chem. Soc. 2012, 134, 16635-16645. DOI: 10.1021/ja305668h

J. M. Mayer. Understanding Hydrogen Atom Transfer: from Bond Strengths to Marcus Theory. Acc. Chem. Res. 2011, 44, 36-46. DOI: 10.1021/ar100093z

Research Interests

Room Number: 
KCL 216