Alanna Schepartz

Alanna Schepartz's picture
Sterling Professor of Chemistry and Professor of Molecular, Cellular & Developmental Biology
Address: 
225 Prospect St, New Haven, CT 06511-8499
203 432 5094

Professor of Molecular, Cellular, and Developmental Biology
Member of Yale faculty since 1988

Research Our lab studies questions that span the combined interfaces of chemistry, biology, medicine, biophysics, and biotechnology. We seek to understand the fundamental chemical mechanisms that control and regulate protein and small molecule interactions in cells and apply this knowledge to both exploit and manipulate cell function as well as drive the development of next-generation therapeutics. Sometimes our goals require the development of new chemical biology tools, while other times we apply state-of-the-art chemical, genomic, structural, or biophysics tools developed by others in new ways. Graduate students hail from all over Yale, including the departments of Chemistry, Cell Biology, Molecular, Cellular, and Developmental Biology and Molecular Biophysics and Biochemistry. But no matter what their background, all students become expert in tools and techniques that span the chemistry-biology-bio-engineering continuum, from organic synthesis to structure determination and from cell biology to genetic engineering.

Education

B.S. State University of New York-Albany, 1982
Ph.D. Columbia University, 1987
NIH Postdoctoral Fellow, Caltech, 1987-88

Honors

Presidential Award for Undergraduate Research, SUNY@Albany, 1982
Award for Excellence in Teaching, Columbia University, 1983
Pegram Award for Graduate Research, Columbia University, 1986
National Institutes of Health Postdoctoral Fellowship, 1987
David and Lucile Packard Foundation Fellow, 1990
Eli Lilly Biochemistry Fellow, 1991
Morse Faculty Fellow, Yale University, 1991
National Science Foundation Presidential Young Investigator Award, 1991
Camille and Henry Dreyfus Teacher-Scholar Award, 1993
Alfred P. Sloan Research Fellowship, 1994
A.C.S. Arthur C. Cope Scholar Award, 1995
A.C.S. Eli Lilly Award in Biological Chemistry, 1997
Dylan Hixon ‘88 Award for Teaching Excellence in the Natural Sciences, Yale University, 1999
Agnes Fay Morgan Research Award, 2002
Howard Hughes Medical Institute Professor, 2002-2007
Editorial Advisory Board, Journal of the American Chemical Society, 2003-2005
Associate Editor, Journal of the American Chemical Society, 2005-2016
Frank H. Westheimer Prize Medal, Harvard University, 2008
ACS Chemical Biology Prize, 2010
Alexander M. Cruickshank Prize, 2010
American Academy of Arts & Sciences Fellow, 2010
American Chemical Society Fellow, 2010
Ronald Breslow Award for Achievement in Biomimetic Chemistry, 2012
Co-Editor, Molecular Imaging, Current Opinion in Chemical Biology, 2012
Co-Editor, Supramolecular Chemistry for Biology, Materials and Medicine, Israel Journal of Chemistry, 2013
Elected Member, National Academy of Sciences, 2014
Editor-in-Chief, Biochemistry, 2016-present
Wheland Medal, University of Chicago

Recent Publications

C.M. Czekster, W.E. Robertson, A.S. Walker, D. Söll, & A. Schepartz. In vivo biosynthesis of a ß-amino acid-containing protein. J. Am. Chem. Soc. 2016, 138, 5194-5197. DOI: 10.1021/jacs.6b1023

R.S. Erdmann, H. Takakura, A.D. Thompson, F. Rivera-Molina, E.S. Allgeyer, J. Bewersdorf, D.K. Toomre, & A. Schepartz. Super-resolution imaging of the golgi in live cells with a bio-orthogonal ceramide probe. Angew. Chem. Int. Ed. Engl. 2014, 53, 10242-10246. DOI: 10.1002/anie.201403349

A. Doerner, R. Scheck, & A. Schepartz. Growth factor identity is encoded by discrete coiled-coil rotamers in the EGFR juxtamembrane region. Chem. Biol. 2015, 22, 776-784. DOI: 10.1016/j.chembio.2015.05.008

J.R. LaRochelle, G.B. Cobb, A. Steinauer, E. Rhoades, & A. Schepartz. Fluorescence correlation spectroscopy reveals highly efficient cytosolic delivery of certain penta-arg proteins and stapled peptides. J. Am. Chem. Soc. 2015, 137, 2536-2541.

Research Interests

Room Number: 
CRB 310