Milton Harris '29 Ph.D. Professor of Chemistry
Professor of Molecular, Cellular, and Developmental Biology
Director, Yale Chemical Biology Institute
Member of Yale faculty since 1988
Research The Schepartz laboratory develops and applies chemical tools to study protein interactions and dynamics inside or between living cells. Our approach centers on the design and synthesis of molecules that nature chose not to synthesize – miniature proteins, β-peptides, and pro-fluorescent cell-permeable ligands - and the use of these molecules to probe questions in current biology that would otherwise be nearly impossible to address. Current topics include the use of miniature proteins to rewire signaling networks that control cell motility and differentiation, the application of β-peptides to self-assemble protein-like quaternary structures entirely devoid of α-amino acids, and the development of small molecule fluorescence strategies to detect misfolded or unfolded proteins inside live cells.
B.S. State University of New York-Albany, 1982
Ph.D. Columbia University, 1987
NIH Postdoctoral Fellow, Caltech, 1987-88
Presidential Award for Undergraduate Research, SUNY@Albany, 1982
Award for Excellence in Teaching, Columbia University, 1983
Pegram Award for Graduate Research, Columbia University, 1986
National Institutes of Health Postdoctoral Fellowship, 1987
David and Lucile Packard Foundation Fellow, 1990
Eli Lilly Biochemistry Fellow, 1991
Morse Faculty Fellow, Yale University, 1991
National Science Foundation Presidential Young Investigator Award, 1991
Camille and Henry Dreyfus Teacher-Scholar Award, 1993
Alfred P. Sloan Research Fellowship, 1994
A.C.S. Arthur C. Cope Scholar Award, 1995
A.C.S. Eli Lilly Award in Biological Chemistry, 1997
Dylan Hixon '88 Award for Teaching Excellence in the Natural Sciences, Yale University, 1999
Agnes Fay Morgan Research Award, 2002
Howard Hughes Medical Institute Professor, 2002-2007
Editorial Advisory Board, Journal of the American Chemical Society, 2003-2005
Associate Editor, Journal of the American Chemical Society, 2005-present
Frank H. Westheimer Prize Medal, Harvard University, 2008
ACS Chemical Biology Prize, 2010
Alexander M. Cruickshank Prize, 2010
American Academy of Arts & Sciences Fellow, 2010
American Chemical Society Fellow, 2010
Ronald Breslow Award for Achievement in Biomimetic Chemistry, 2012
Co-Editor, Molecular Imaging, Current Opinion in Chemical Biology, 2012
Co-Editor, Supramolecular Chemistry for Biology, Materials and Medicine, Israel Journal of Chemistry, 2013
D.S. Daniels, E.J. Petersson, J.X. Qiu, & A. Schepartz. High resolution structure of a ß-peptide bundle. J. Am. Chem. Soc. 2007, 129, 1532-1533. Highlight: Chem. Eng. News 2007, 85(6), 7; Highlight: Chem. Eng. News 2007, 85(52), 13-19; Highlight: Faculty of 1000 Biology: http://www.f1000biology.com/article/id/1071733/evaluation. Chosen as one of the "most important advances in Chemistry during 2007": http://pubs.acs.org/cen/coverstory/85/8552cover.html
R.J. Dexter & A. Schepartz. Direct visualization of protein association in living cells with complex-edited electron microscopy. Angew. Chem. 2010, 49, 7952-7954.
E.M. Hobert & A. Schepartz. Rewiring kinase specificity with a synthetic adaptor protein. J. Am. Chem. Soc. 2012, 134, 3976-3978.
J.S. Appelbaum, J.M. LaRochelle, B.A. Smith, D.M. Balkin, J.M. Holub, & A. Schepartz. Arginine topology controls escape of minimally cationic proteins from early endosomes to the cytoplasm. Chem. Bio. 2012, 19, 819-830.
R.A. Scheck, M.A. Lowder, J.S. Appelbaum, & A. Schepartz. Bipartite tetracysteine display reveals allosteric control of ligand-specific EGFR activation. ACS Chem. Bio. 2012, 7, 1367-1376.